Compound Comparison
Compare peptides side by side. See the differences that matter when choosing between similar compounds.
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COMMON COMPARISONS
| Attribute | Retatrutide | Tirzepatide | Semaglutide |
|---|---|---|---|
| Category | GLP-1 (Triple Agonist) | GLP-1 (Dual Agonist) | GLP-1 (Pure Agonist) |
| Primary Use | Weight loss / fat reduction | Weight loss / Type 2 diabetes | Weight loss / Type 2 diabetes |
| Mechanism | Activates GLP-1, GIP, and glucagon receptors. Glucagon arm increases BMR and fat oxidation. | Dual GLP-1/GIP agonist. GLP-1 handles appetite, GIP improves insulin sensitivity. | Pure GLP-1 receptor agonist. Slows gastric emptying, increases satiety, improves insulin release. |
| Typical Dose | 2-8mg weekly (titrate from 2mg) | 5-10mg weekly (titrate from 2.5mg) | 1.0-2.4mg weekly (titrate from 0.25mg) |
| Frequency | Once weekly | Once weekly | Once weekly |
| Half-Life | ~6 days | ~5 days | ~7 days |
| Common Side Effects | Nausea, heartburn, sulfur burps, constipation, fatigue | Nausea, constipation, fatigue, heartburn | Nausea, vomiting, diarrhea, constipation |
| GI Side Effect Severity | High (strongest GI sides of the three) | Moderate (gentler than reta, similar to sema) | Moderate (some users report extreme nausea) |
| Cycle Length | 12-16 weeks typical, can run longer | 6-12 months continuous or cycles | 6-12 months continuous |
| Best For | People with 30+ lbs to lose, metabolic syndrome, visceral fat targeting | People with 20-40 lbs to lose, prediabetes, sustainable long-term use | People with 15-30 lbs to lose, first-time GLP-1 users, proven track record |
| Key Differentiator | Strongest weight loss (up to 24% reduction), increases metabolic rate via glucagon arm | Best balance of efficacy and tolerability, dual-agonist mechanism | Most established data, FDA-approved longest, pure GLP-1 mechanism |
High-Level Overview
This comparison shows key attributes at a glance. For full context on mechanisms, protocols, side effect management, and PH considerations, read the complete compound pages.
No Universal Best
There's no single "best" compound. The right choice depends on your goals, tolerance for side effects, experience level, and what you're willing to commit to. What works for someone else might not work for you.
Comparison tool only. This tool provides high-level comparisons for educational purposes. Always consult a qualified healthcare professional before starting any peptide protocol.